Symbol
Name
ID

Pclo
piccolo (presynaptic cytomatrix protein)
MGI:1349390

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Progressive microcephaly

Spasticity

Hypoplasia of the pons

Hypoplasia of the brainstem

Atrophy/Degeneration affecting the brainstem

Hypoplasia of the corpus callosum

Reduced cerebral white matter volume

Cerebral atrophy

Cerebellar hypoplasia

Cerebellar atrophy

Hyperreflexia

Global developmental delay

Seizure

Disease(s) Associated with PCLO

pontocerebellar hypoplasia type 3

Mouse Phenotypes		nervous system phenotype	abnormal synaptic vesicle number	abnormal CNS synaptic transmission	increased excitatory postsynaptic current amplitude	increased synaptic depression	increased neurotransmitter release
Availability	Mouse Genotype	nervous system phenotype	abnormal synaptic vesicle number	abnormal CNS synaptic transmission	increased excitatory postsynaptic current amplitude	increased synaptic depression	increased neurotransmitter release
	Pclo^tm1.1Mver/Pclo^tm1.1Mver
	Pclo^tm3.2Sud/Pclo^tm3.2Sud	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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